Network-Wide Screen Identifies Variation of Novel Precise On-Module Targets Using Conformational Modudaoism
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چکیده
منابع مشابه
Network‐Wide Screen Identifies Variation of Novel Precise On‐Module Targets Using Conformational Modudaoism
Modular targeting is promising in drug research at the network level, but it is challenging to quantificationally identify the precise on-modules. Based on a proposed Modudaoism (MD), we defined conserved MD (MDc) and varied MD (MDv) to quantitatively evaluate the conformational and energy variations of modules, and thereby identify the conserved and discrepant allosteric modules (AMs). Compare...
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ژورنال
عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology
سال: 2017
ISSN: 2163-8306
DOI: 10.1002/psp4.12253